Several conditions can lead to cirrhosis of the liver, which can affect the function of the liver. If portal hypertension is present, patients can experience GI bleeding due to esophageal, gastric, or rectal varices. In addition, they can develop ascites, or fluid in the abdomen, which can cause significant distension and discomfort. IR plays an important role in the care of these patients by performing biopsies to diagnose liver disease, draining ascites to improve patient comfort, and performing TIPS procedures to reduce reduce portal venous pressures.